Toxicological effects of dietary biogenic amines core. For cadaverine, histamine, phenylethylamine, putrescine and tyramine this was only approximately a sixth of. Refrigeration can be used to inhibit histamine formation during these processes fda, 2011. They can be formed in fermented foods such as cheese, wine, beer, sausages and fish products brink et al. Biogenic amines in foods have relevance from both safety and quality standpoints. Euiii heterobimetallic complexes, kruiitbubpycn42euiiih2o4 where tbubpy 4,4. Another amine, histamine, has been implicated as the causative agent in several outbreaks of food poisoning. Biogenic amines in cheese and other fermented foods. Pdf toxicological effects of dietary biogenic amines. Presence of higher concentrations of toxic biogenic amines in food is undesirable and indicates the.
The most significant bas occurring in foods are histamine, tyramine, putrescine, cadaverine, tryptamine, 2phenylethylamine, spermine, spermidine, and agmatine. The eight biogenic amines, which are the most important to be determined in food samples, were derivatized with dansyl chloride prior to uplc. The most common biogenic amines found in foods are histamine, tyramine, cadaverine, 2phenylethylamine, spermine, spermidine, putrescine, tryptamine, and agmatine. Amines are found naturally in some fruits and vegetables, however in the case of meat, dairy products, alcoholic drinks and other fermented foods, amines are usually formed by bacterial degradation. Putrescine was the main amine formed both in aerobically and mapackaged chicken samples. Biogenic amines play important roles in many human and animal physiological functions such as regulation of body temperature, stomach volume, stomach ph and brain activity ten brink, 1990. The term encompasses constituents, secretions, and metabolites of plants or animals. The most common bas in foods are histamine, tyramine, putrescine and cadaverine table 2.
Browning, grilling, charring will increase amine level in comparison with food cooked by microwave or steaming. Biogenic amines are produced by bacterial decarboxylation of corresponding amino acids in foods. A rapid ultraperformance liquid chromatographic uplc method for the determination of biogenic amines putrescine, cadaverine, spermidine, spermine, phenylethylamine, histamine, tyramine and tryptamine in selected food samples is described. Taken up in large amounts, they can cause severe poisoning. The concentration of amines formed in foods depends on the type of microorganisms present, the action of decarboxylase enzymes produced by microorganisms on specific amino acids. The formation of biogenic amines and their correlation to microflora and sensory characteristics of a precooked chicken meat product stored aerobically and under modified atmosphere packaging map 30% co2, 70% n2 was studied. A crossroads where medicine, nutrition, pharmacy, and food industry converge.
Biogenic amines definition of biogenic amines by medical. Bas formation is possible during processes such as brining, salting, smoking, drying, fermenting, and pickling until the product is fully shelfstable table table3. Biogenic amines, such as histamine and tyramine, are found in fruits, vegetables, and meats. Foodfermenting lactic acid bacteria lab are generally considered to be non toxic and nonpathogenic. Histamine and tyramine are considered as the most toxic and food safety. Biogenic amines and their production by microorganisms in food. Biogenic amines bas are lowmolecularweight organic bases that are common constituents of many foods. Bacterial diversity, biogenic amines and lipids oxidation. They are described as low molecular weight organic bases with aliphatic, aromatic, and heterocyclic structures. Effects of biogenic amines on broiler performance pdf. Krautwurst, in trace amines and neurological disorders, 2016. Concentrations of the biogenic amines, tryptamine, phenylethylamine, putrescine, cadaverine, histamine, tyramine, spermidine and spermine were analysed in 55 samples of canned pet dog and cat food.
Fortunately, identifying and avoiding amine containing foods can help to significantly reduce pain and stress. A qualitative risk assessment of biogenic amines ba in fermented foods was conducted, using data from the scientific literature, as well as from european unionrelated surveys, reports and consumption data. Biogenic amines bas are defined as low molecular weight organic bases with biological activity. Biogenic amine definition of biogenic amine by medical. For humans, the ingestion of small amounts of biogenic amines is harmless. A biogenic substance is a product made by or of life forms. However, processed foods that combine large amounts of biogenic amines are known for triggering headaches and migraines. They play a crucial role in maintaining neurotransmitters study link. Biogenic amines in foods may pose a public health problem. Biogenic amines and their respective metabolites are parameters for the diagnosis of a number of diseases such as phaeochromocytoma or other tumours of the nervous system. Reliable results in routine diagnostics are therefore of clinical significance. Direct analysis of biogenic amines in food by hilicms. Certain foods contain biogenic amines that can add to the amounts naturally present in the body. Amines are lowmolecularweight organic bases which can be formed and degraded during the normal metabolism of animals, plants and microorganisms.
In the human diet, their excessive intake can cause food poisoning. Biogenic amines have been shown to occur in various foods like fish, meat, cheese, vegetables, and wines. Samples of fermented fish products fish sauce, fish paste, and shrimp paste were analyzed for. Biogenic amines bas are molecules, which can be present in foods and, due to their toxicity, can cause adverse effects on the consumers. Formation of biogenic amines in all foods of animal origin having high protein contents, as well in. Depending on the type of amine, 75% levels of the results varied from 5. The average biogenic amine content of the liquors varies considerably from 1 geographical region to another. Simple detection method of biogenic amines in decomposed fish by intramolecular excimer fluorescence 1021 in fact the fish such as families scombridae e.
Some people, however, seem to have a more general sensitivity to amines. Biogenic amines are natural antinutrition factors and are important from a hygienic point of view as they have been implicated as the causative agents in a number of food poisoning episodes, and they are able to initiate various pharmacological reactions. Biogenic amines ba are lowmolecularweight nitrogenous organic bases, which can accumulate in high concentration in food due to microbial activity and cause toxic effects in consumers. Biogenic amines in food products on the belgian market. Biogenic amines can be found in a variety of feed and food for example fish, meat, wine, cheese and other fermented food products. Biogenic amines in food products on the belgian market lisa miclotte promotoren. Biogenic amines in foods 1 biogenic amines in foods maoi drugs. The synthesis and accumulation of ba in food requires the presence. Category negligible low moderate high very high fruit apple blackcurrant dates avocado apricot grapefruit kiwifruit banana gooseberry honeydew lime fig peach red. Impact of biogenic amines on food quality and safety mdpi. Biogenic amineinduced and taarmediated cellular functions in isolated blood leukocytes.
Diets low in food chemicals usually include amines in this more general way. Biogenic amines in fermented foods european journal of clinical. Control of biogenic amines in foodexisting and emerging. The reasons to monitor biogenic amines in food products are to determine that the food is suitable for consumption and to establish appropriate storage conditions.
Occurrence of biogenic amines and amines degrading. Occurrence of biogenic amines and amines degrading bacteria in fish sauce muhammad zukhrufuz zaman1, fatimah abu bakar1, jinap selamat1 and jamilah bakar2 1department of food science and 2department of food technology, faculty of food science and technology, universiti putra malaysia, serdang, selangor, malaysia. Ppt biogenic amines in foods powerpoint presentation. Beverages free fulltext biogenic amines in alcohol.
Concentration of biogenic amines in fermented food products is affected by several factors in the manufacturing process, including hygienic of raw materials, microbial composition, fermentation condition, and the duration of fermentation. The biogenic amines most commonly found in foods are cadaverine, putrescine, tyramine. Fortunately, identifying and avoiding aminecontaining foods can help to significantly reduce pain and stress. Bas are generally produced by microbial decarboxylation of amino acids in food products. Formation of biogenic amines can occur during food processing and storage as a result of bacterial activities. Presented in several types of food, bioactive amines are described as organic bases of low molecular weight. Consequently, higher amounts of certain amines may be found in food as a consequence of the use of poor quality raw materials, microbial contamination and inappropriate food processing conditions or microbial contamination and. The analysis of biogenic amines by standard and novel. Kohajdova department of food technology, faculty of chemical and food technology, slovak university of technology, sk812 37 bratislava email. Laser scribed graphene biosensor for detection of biogenic. A biogenic amine is a biogenic substance with one or more amine groups. Biogenic amineforming microbial communities in cheese.
Nonetheless, consumption of food or beverages containing high amounts of these compounds can have toxic effects such as hypertension, cardiac palpitations, headache, nausea. Biogenic amines are found in varying concentrations in a wide range of foods fish, cheese, meat, wine, beer, vegetables, etc. On the occurrence of biogenic amines in petfood for cats. Firman department of animal sciences, college of agriculture, 116 animal science research center, university of missouri, columbia, mo 65211 phone.
Amine content of selected foods very few foods have been tested systematically for amine content. In food and beverages, biogenic amines are formed by the enzymes of raw material and generated by microbial decarboxylation of amino acids. In food, especially in alcoholfree beverages, biogenic amines can be synthesized by enzymes, naturally present in raw materials, or by microorganisms, which may be naturally present. In foods, high levels of biogenic amines ba are the result of microbial metabolism that could be affected by temperatures and storage conditions. Thus, the level of ba is commonly used as an indicator of food safety and quality. This is why chromsystems developed a range of reliable ceivd solutions.
Scientific opinion on risk based control of biogenic amine. The names of many ba correspond to the names of their originat ing amino acids. Biogenic amines are present in proteinrich food such as fish, meat or milk. These biogenic amines include amongst their number histamine, phenylethylamine, serotonin, and tyramine. Biogenic amines are ubiquitous bioactive compounds that are synthesized by living organisms and perform essential functions for their metabolism. Biogenic amines in raw and processed seafood europe pmc. Biogenic amines ba are nitrogenous compounds of low molecular weight and are essential at low concentrations for natural metabolic and physiological functions in animals, plants and microorganisms. Biogenic amines in fermented foods european food safety. Concentration of biogenic amines in fermented food products is affected by several factors in the. Amine content of selected foods the failsafe diet explained.
The main biogenic amines extracted were putrescine and spermidine and the total biogenic amine content was higher at 25 c than at 15 c. They may be found in a wide range of foods containing proteins or free amino acids including meat, dairy and fish products, vegetables, fruits, wine, beer, nuts and chocolate. Request for data on biogenic amines in food european. Pdf on may 18, 2015, giovanna suzzi and others published editorial. Knowledge of the biogenic amine ba levels in food is important for assessing health hazards, for example, they can cause some neurotransmission disorders due to their action as false neurotransmitters silla santos, 1996. In addition octopamine and dopamine have been found in meat and meat products and fish hernandezjover and others 1996. Toxicological effects of dietary biogenic amines bentham. Simple detection method of biogenic amines in decomposed. A chemodosimetric detection assay has been developed for those gaseous amines by ruii.
Gaseous biogenic amines such as putrescine, spermidine, aniline, and trimethylamine are important biomolecules that play many crucial roles in metabolism and medical diagnostics. Biogenic amine contents in selected egyptian fermented. Biogenic amines are organic bases with low molecular weight and are synthesized by microbial, vegetable and animal metabolisms. They have vasoactive, psychoactive and toxicological characteristics and constitute a potential health risk. They are formed and degraded as part of the normal metabolism of microorganisms, plants and animals, in which they have important physiological. Markus eriksson master thesis submitted in partial fulfillment of the requirements for the degree of master of science in bioengineering food science and. Biogenic amines in foods food biochemistry and food. High intake of these foods could upset the balance of biogenic amines in the body to cause health problems such as hypotension, hypertension, gastrointestinal distress, headaches and migraine, and others.
Therefore, histamine, tyramine, putrescine, cadaverine, spermine, and spermidine concentrations were measured in selected food items commonly consumed in egypt. Pdf impact of biogenic amines on food quality and safety. This manuscript outlines the development of laser scribed graphene electrodes, with locally sourced materials, for reagentfree food safety biosensing. They are basic nitrogenous compounds formed mainly by decarboxylation of amino acids or by amination and transamination of aldehydes and ketones. Biogenic amines, food products, physiology, toxicology, microbiology, regulation. Moreover the presence of bas can cause headaches, nausea and palpitations, especially if some monoamine oxidase mao inhibitors are also ingested as drugs. Technological factors affecting biogenic amine content in. Chapter 1 biogenic amines formation, toxicity, regulations in food. Their concentration increases during food decomposition. Large amounts of bas can be found in foods such as cheese, fermented vegetables, fish and fish products, wine, dried meat products, and.